April 15, 2026
IN THIS ISSUE / April 15, 2026
Benefits, misconceptions, and risks of skin care supplements
DermWorld What’s Hot: Using a RegiSCAR score to evaluate DRESS
FDA approves dermal filler for treating wrinkles in décolleté area
Local recurrence, survival in patients with melanoma in situ
Benefits, misconceptions, and risks of skin care supplements
Authors of an article published in the International Journal of Women’s Dermatology discussed common misconceptions, possible benefits, and potential side effects of the most commonly used antiaging skin supplements used by women, including biotin, nicotinamide, hyaluronic acid, collagen, zinc, vitamin C, vitamin A, and vitamin E, among others.
[Are nutritional supplements aimed at skin care helpful, harmful, or placebo for patients? Read more.]
Although there are some supplements that may be helpful in prevention, such as nicotinamide and active forms of vitamin A for photoaging, the evidence is weak for most supplements other than in patients who are truly deficient, the review noted. Supplements may also interfere with common blood tests, such as biotin with the thyroid and troponin cardiac enzyme tests. Other supplements, such as zinc, are commonly taken in excess and may result in deficiencies in the absorption of other minerals, such as copper. Over-supplementation of fat-soluble vitamins, such as vitamin A and vitamin E, can result in toxic levels since excess is not excreted in the urine. According to the authors, dermatologists must ask their patients about supplement use and be aware of their potential harms.
Dermatologists discuss considerations and complexities in caring for older adults with skin cancer. Read more.
DermWorld What’s Hot: Using a RegiSCAR score to evaluate DRESS
A 65-year-old woman was hospitalized for a diffuse, morbilliform eruption on her trunk and extremities. Her face was erythematous and her eyelids were so swollen that she could barely open them. She had a low-grade fever and transaminitis. The patient had started taking sulfamethoxazole/trimethoprim for a swollen joint two weeks prior to the onset of her eruption. Based on the patient’s RegiSCAR score, the dermatology consult team deemed that this was not a case of drug reaction with eosinophilia and systemic symptoms (DRESS), but instead, this was a case of viral exanthem. Read more from Sylvia Hsu, MD, FAAD.
AAD seeks member comments for HS guidelines
The Academy is seeking member comments on the draft of the hidradenitis suppurativa clinical guidelines for diagnostic testing. The guideline workgroup, which includes experts in HS management and a patient representative, will review your comments and edit the guidelines based on your feedback if applicable. Read the draft guidelines and submit your comment by April 28.
FDA approves dermal filler for treating wrinkles in décolleté area
The FDA approved a subdermal implant (Radiesse®) for treating wrinkles and adding volume in the décolleté area. Pivotal trial data showed that after a year, more than 80% of patients felt satisfied with skin tightness and 83% said they would undergo treatment again. The product is also approved for treating wrinkles of the hands or face.
The filler contains hydroxylapatite microspheres that can appear on X-rays and CT scans, potentially interfering with breast imaging. The FDA is requiring a 30-patient postmarketing study to determine whether treatment in the décolleté area interferes with radiographic imaging of breast tissue.
Local recurrence, survival in patients with melanoma in situ
A study published in JAMA Dermatology investigated local recurrence and prognosis in non-lentigo maligna/non-acral lentiginous melanoma in situ (MIS). This retrospective cohort study included patients with MIS who were followed up for at least one year, with a median follow-up of 5.2 years.
[Take the Making Sense of the Expanding Molecular Toolbox for Skin Cancer Diagnosis course and earn 6 CME credits.]
All lesions were initially treated with excisional biopsy, followed by wide excision for the majority of the participants. There was only one local recurrence in a patient with involved margins at the excisional biopsy who did not undergo wide excision. Thirty lesions in 30 patients had clear excisional biopsy margins with no wide excision and had no recurrence at a median follow-up of eight years. In 23 patients with 23 lesions that had wide excision with narrower than 0.5-cm margins, no recurrences were found at a median follow-up of 4.3 years. No patients had metastasis or melanoma-specific death. The authors concluded that diagnostic excisional biopsies with clear margins may be sufficient for treating MIS, although larger studies are necessary.
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