Efficacy of various concentrations of retinol in middle-aged women
In a split-face trial published in the Archives of Dermatological Research, women aged 40-59 years applied either retinol 0.045% and 0.075% cream or retinol 0.1% and 0.2% cream for 24 weeks. The measurement parameters for aging were crow’s feet, forehead wrinkles, nasolabial fold, dermal density, and elasticity and parameters for skin color were skin brightness, yellowness, redness, and standard deviation of skin brightness. The texture of the skin was determined by measuring the skin roughness and pores, and the skin barrier function was evaluated through hydration, sebum, and desquamation.
Skin aging parameters, color brightness, and skin texture significantly improved at all concentrations. The rate of improvement was faster with higher concentrations of retinol, although at 24 weeks, there was no significant difference in the effect.
Which cosmeceuticals have proven clinical efficacy? Read more in DermWorld Weekly.
DermWorld Insights and Inquiries: For the win! Championing the use of the term ‘reactive granulomatous dermatitis’ in clinical practice
Growing up in the 1980s in suburban St. Louis, Missouri, I spent many evenings listening to Cardinals’ baseball on the local AM radio station, KMOX 1120. After the final out of each Cardinals’ victory, the late Hall-of-Fame broadcaster, Jack Buck, would emphatically say, “That’s a winner!” Similarly, when Rosenbach and English coined the term “reactive granulomatous dermatitis” (RGD) in 2015, I thought that this was a “winning” concept. They proposed RGD as a unifying term to encompass interstitial granulomatous dermatitis (IGD), palisaded neutrophilic and granulomatous dermatitis (PNGD), and interstitial granulomatous drug reaction (IGDR). I wish that RGD had been part of our vernacular during my dermatology residency and early faculty years. Keep reading!
Member comment period for new AD guidelines is open
The AAD is seeking member comments on its draft clinical practice guidelines on the management of atopic dermatitis (AD) in adults using phototherapy and systemic agents. These guidelines appraise evidence of the efficacy and safety of phototherapy and systemic agents for AD. The development of these guidelines followed a systematic approach and recommendations were formed by a guideline work group that includes experts in AD management from multiple clinical settings, a methodologist, and a patient representative.
Should deep shave removal be considered for suspected BCC?
In a prospective study published in Dermatologic Surgery, deep shave removal with the intent to remove the entire tumor was performed on 77 suspected basal cell carcinomas (BCCs) in 51 patients. Overall, five lesions (6%) were not BCCs but were benign in nature. A total of 15 lesions (21%) had positive margins.
BCCs with positive margins tended to have nodular histopathology and be located on the trunk. Overall, 14 specimens with initial negative margins were chosen for resectioning, and positive margins were found in four specimens (28.6%). The authors conclude that deep shave removal could be considered for low-risk BCCs on the trunk or extremities in immunocompetent patients hoping to avoid a second treatment visit.
Changes to TNM system enhance prognostication for cutaneous cancers. Read more in DermWorld.
Former AADA President David Pariser, MD, FAAD, attends President Biden speech, urges president to oppose Medicare cuts
On Tuesday, Feb. 28, former AADA President David Pariser, MD, FAAD, attended a speech with President Joe Biden in Virginia Beach. Having an AADA representative invited to the speech is a testament to the AADA’s strong footprint in Washington, D.C. In his remarks, President Biden spoke about strengthening and protecting Social Security, Medicare, and Medicaid. The speech highlighted the president’s health care priorities ahead of the release of President Biden’s budget on March 9. Sens. Tim Kaine (D-VA) and Mark Warner (D-VA) and Rep. Bobby Scott (D-VA) also attended the event, along with numerous local elected officials.
After the speech, Dr. Pariser had the opportunity to meet the president and stressed the importance of preserving patients’ access to care by opposing cuts to Medicare and Medicaid. Medicare physician payment reform, including securing a positive inflationary adjustment for Medicare payments, is the top advocacy priority of the AADA.
Contact your representatives and urge them to reform Medicare physician payment by using the AADA Action Center at takeaction.aad.org.
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