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October 30, 2019


IN THIS ISSUE / October 30, 2019


Potential treatment for chronic urticaria may offer complete control

According to a study recently published in the New England Journal of Medicine, ligelizumab (currently in phase 3 trials) may be a safe and effective treatment option for chronic spontaneous urticaria. Study authors randomly assigned 382 patients to receive a single 120-mg dose of ligelizumab (or doses of 24 mg, 72 mg, or 240 mg), omalizumab (300 mg), or placebo every four weeks for 20 weeks. A higher percentage of patients had complete control of symptoms of chronic spontaneous urticaria with the 72 mg or 240 mg of ligelizumab therapy than with omalizumab or placebo.

The researchers found that at week 12, the ligelizumab group — 30%, 51%, and 42% of patients treated with 24 mg, 72 mg, and 240 mg, respectively — had a complete hives response versus 26% of the patients in the omalizumab group and no patients in the placebo group. At week 12, 30%, 44%, and 40% of the patients treated with the varied doses of ligelizumab had complete control of symptoms compared to 26% of patients in the omalizumab group and no patients in the placebo group.

View the most recent joint guidelines for urticaria on aad.org.

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DW Insights and Inquiries: Can chowing down improve pseudoxanthoma elasticum?

Dr. Heymann headshot
I have diagnosed pseudoxanthoma elasticum (PXE, OMIM # 264800) a few times in my career. The immediate excitement of rendering the diagnosis is quickly tempered by the realization that so far there is no definitive treatment for this devastating disease. PXE is an autosomal recessive disease characterized by ectopic mineralization and fragmentation of the elastic fibers. PXE manifests in the skin (yellow papular lesions with increased skin laxity in flexural areas), eyes (angioid streaks and subchoroidal neovascularization with hemorrhage), and cardiovascular system (peripheral occlusive disease, coronary, and cerebrovascular artery disease). There may be marked phenotypic variability between patients. Keep reading!


Advances in medical technology: friend or foe?

Jenna O’Neill, MD, DW Young Physician Advisor
Who are we? Where did we come from? We scientists are an inquisitive lot, but these questions are pervasive across all cultures and throughout history. I imagine that cave men and women also pondered on their prehistoric origins, when not busy fleeing predators or foraging for food. I remember marveling at a 3D model of DNA in middle school science class; at that time, the building block of life was largely a mystery waiting to be unlocked. Fast forward not so many years later, now sequencing of your own DNA is a postage stamp away! Read more from DW Young Physician Advisor Jenna O’Neill, MD.


October Cracking the Code Quiz


Do U.S. dermatology residents suffer from imposter syndrome?

In a soon-to-be published JAAD study, authors examined the prevalence of imposter syndrome (IS) — a condition that causes persistent feelings of self-doubt and skepticism — among U.S. dermatology residents and determined whether there is a correlation with physician burnout.

Of the 121 dermatology residents surveyed, 89% (108) had IS with moderate to intense imposter tendencies. IS was more frequent in females compared to males (92% vs. 85%). Also, 56% of respondents had burnout in at least one of the medical personnel burnout scale categories. The study’s authors recommended strategies to address IS, such as professional mentorship and feedback that acknowledges efforts and accomplishments, to be developed to help residents deal with feelings of self-doubt.

Feeling stressed? Check out the Academy’s Derm360 resources to help physicians combat burnout, and read about sources of dermatologist burnout and strategies on how to cope in Dermatology World.

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Academy testimony prompts congressional support for prior auth bill

Several congressional members within the House Committee on Small Business recently shared their support for the Improving Seniors’ Timely Access to Care Act of 2019, which will help streamline the prior authorization process for Medicare Advantage plans.

Last month, Academy member Howard Rogers, MD, PhD, testified on the burdens of prior authorization to the committee. Learn more about what the AADA is doing to reduce the burdens of prior authorizations.

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Syphilis and STDs on the rise for fifth year in a row

Despite data showing that young people are less sexually active than older generations at the same age, they’re still contracting more sexually transmitted diseases than any other group — and the rates of infection are accelerating, reports the The Wall Street Journal.

According to a recent Centers for Disease Control and Prevention (CDC) report, in 2018, rates of sexually transmitted diseases in the United States increased for the fifth year in a row and combined cases of syphilis, gonorrhea, and chlamydia reached a record high with half the reported infections occurring in young adults ages 15 to 24. Among all age groups, rates of chlamydia increased 3% from 2017, gonorrhea increased by 5%, and syphilis by 14%. Among the most concerning findings from the CDC’s report is the rapid increase in prevalence of congenital syphilis, which increased 22% from 2017 to 2018.

With the resurgence of syphilis, what role do dermatologists play? Find out in Dermatology World.

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