Is there an association between isotretinoin and sexual dysfunction?
Authors of a report in JAAD assessed whether isotretinoin is associated with sexual dysfunction (SD) in patients with acne. Patients who were prescribed isotretinoin were compared to patients who were prescribed topical retinoids for two years.
[Oral vs. topical finasteride: Sexual, neuropsychiatric AEs. Read more.]
Of isotretinoin-treated patients, 1.3% had a SD diagnosis, with dyspareunia (47%) and erectile dysfunction (27%) being the most common. Patients with SD versus those without SD diagnosis were older, more often male (26% vs. 21%), and more likely to identify as white (64% vs. 58%), with a median SD diagnosis at 323 days. The authors found no positive association between isotretinoin and SD in males and females.
Is isotretinoin linked to psychiatric events for acne patients? Read more.
DermWorld Insights and Inquiries: Exploring the gamut of monoclonal gammopathy of cutaneous significance
One of our favorite board-review books during my dermatology residency was Dermatology Quick Glance, authored by Drs. Saeed Jaffer and Abrar Qureshi in 2004. My coresidents and I would periodically meet during the few months before the annual in-service exam to review its chapters and quiz each other about pertinent pearls. In the “High-Yield Factoids” chapter there was a section on “Paraproteinemias Associated with Skin Changes,” and I remember us asking one another in rapid-fire succession, “What condition is associated with IgM kappa monoclonal gammopathy?” (Schnitzler syndrome); “What subtype of monoclonal gammopathy is most commonly seen with neutrophilic dermatoses?” (IgA); “What are the typical paraproteins associated with scleromyxedema and necrobiotic xanthogranuloma?” (IgG lambda and IgG kappa, respectively). But why is it clinically important for us to know the associations between monoclonal gammopathies and skin disorders? Keep reading!
Is there an association between food allergies and atopic dermatitis?
Authors of a study published in Pediatric Dermatology investigated the impact of food allergy (FA) status on atopic dermatitis (AD) control and persistence. They analyzed 8,015 children, exploring the relationship between FA status as an exposure and AD control as an outcome at enrollment, as well as AD persistence as another outcome over 10 years. The results showed that at enrollment, children with any FA had significantly higher odds of having uncontrolled AD, and over the course of 10 years, they were more likely to experience persistent AD compared to those without any FA. These associations were pronounced with milk, egg, and peanut allergies. The authors highlighted the importance of recognizing FA as a significant prognostic factor in managing long-term AD outcomes in comorbid cases.
An article published in Pediatrics analyzed TikTok videos featuring skin care regimens with content creators aged 18 years or younger. Two investigators each created a new TikTok account, reporting themselves to be 13 years old. The “For You” tab was used to view relevant content until 100 unique videos were compiled.
[How can dermatologists counsel teens, tweens, and their parents on safe skin care practices? Read more.]
Each video had an average of 1.1 million views. Regimens featured an average of six products, costing an average of $168/regimen. Only 26% of the videos included sunscreen. The top 25 most-viewed videos contained an average of 11 and a maximum of 21 potentially irritating active ingredients. Twenty of the inactive ingredients are included in the Pediatric Baseline Series.
Dermatologists discuss popular social media trends impacting the skin. Read more.
Antifungal resistance of the T. mentagrophytes/T. interdigitale species complex
A study published in the Journal of The European Academy of Dermatology & Venereologyevaluated the features of antifungal-resistant Trichophyton mentagrophytes (T. mentagrophytes/Trichophytoninterdigitale (T. interdigitale) species complex and monitored the prevalence of Trichophyton indotineae (T. indotineae).
[With increasing resistance to antifungal therapies, here’s what dermatologists need to know about managing dermatophytosis. Read more.]
One hundred and twenty strains (52.2%) were T. mentagrophytes, 92 (40.0%) were T. interdigitale, and 18 (7.8%) were T. indotineae. Among T. mentagrophytes isolates, tinea faciei (44.2%) was the common clinical type. T. interdigitale isolates were mainly found in onychomycosis (36.9%), and T. indotineae was commonly isolated from tinea corporis (94.4%) and tinea cruris (55.6%). Antifungal susceptibility testing showed that all isolates of T. interdigitale and T. mentagrophytes were susceptible to terbinafine and voriconazole. All isolates of T. indotineae were resistant to terbinafine.
Access Academy resources on emerging dermatophytes, including diagnoses, treatment, and a registry to report your cases.
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